Vaccine and cell therapy products

The 10HM is a fully manual manipulator designed for safe and reliable handling of multi-layer cell culture flasks with up to 10 layers. Ideal for research, production, and GMP-compliant workflows, it allows precise media addition and removal even in limited spaces such as biosafety cabinets. Its robust stainless steel construction ensures durability and easy cleaning, making it perfect for cleanroom environments.

Features

• Compatibility: Fully compatible with multi-layer CellSTACK (Corning) and Cell Factory (Thermo Fisher) flasks.
• Safe filling and emptying: Gas-damping assistance allows secure handling of flasks, minimizing strain and ensuring consistency.
• Easy operation: Four-step workflow for standard media addition and removal.
• Optimized for biosafety cabinets: Designed to work within limited front openings (approx. 200–250 mm).
• Fully manual: Requires no electricity, compressed air, or external utilities.
• Durable construction: Stainless steel (SUS304) with mirror-polished surfaces for easy cleaning and long-lasting use.

Typical areas of application:

• Handling of 4/5/10-layer cell culture flasks in research and production
• Media changes in multi-layer flasks
• GMP-compliant or aseptic cell culture processes

The MaxCell MLF is a high-capacity CO₂ incubator designed specifically for large-scale cell production using multi-layer flasks.

Features

• Multi-layer flask compatibility: Supports 40- or 52-layer flasks (e.g., Cell Factory, CellSTACK, HYPERStack).
• Model options: Available in single- or dual-chamber configurations; a 4-chamber model is also available, accommodating up to 16 flasks.
• Forced CO₂ gas infusion: A specialized model delivers CO₂ directly into each flask layer to ensure stable CO₂ concentrations and pH levels.
• Easy gas connections: Gas lines with quick-release valves allow secure and tight connections.
• Front window & LED lighting: Large viewing window and internal illumination enable visual inspection without opening the door.
• Touch panel: Multifunctional LCD touchscreen displaying operation logs, flask count, control parameters, and more.
• External recorder (optional): Can be added to log critical control parameters.
• Special carrier & cart: A dedicated transport cart simplifies loading and unloading of multi-layer flasks.

Typical areas of application:

• Large-scale production of adherent cells (e.g., for cell therapy)
• Viral vector manufacturing
• Exosome or protein production
• GMP-compliant cell culture processes

The HSF Reactor is a high-efficiency jar fermenter designed for cultures with high oxygen transfer requirements, such as microorganisms, plant cells, yeast, and E. coli. Its robust architecture enables seamless scaling from laboratory volumes (3–10 L) to larger production systems.

Features

• High-efficiency agitation: Equipped with the HS100 turbine and axial high-flow HR100 impeller for powerful mixing and excellent gas absorption (kLa).
• Scalable design: Compatible with S-BOX control systems for reliable scale-up to production reactors.
• Precise temperature control: Band heater with PID regulation (up to 80 °C); optional in-tank cooling coil.
• Seal-less magnetic drive: Eliminates mechanical seals, reducing leakage and contamination risks.
• Advanced aeration: Includes a ring sparger; Satake sparger available for enhanced gas dispersion.
• Wide speed range: 5–1,500 rpm.
• Temperature accuracy: ±0.3 °C at standard setpoint (37 °C).
• Reactor sizes: Available in 2.4 L and 6 L models.
• Power supply: AC 100 V, 50/60 Hz.

Typical areas of application:

• High-OTR microorganism cultures
• Plant or fungal cell cultivation
• Yeast and E. coli fermentation
• Processes requiring strong mixing and efficient gas transfer

The MRF Reactor is a compact laboratory bioreactor featuring a rotating impeller that provides powerful, uniform mixing with low shear stress. Designed for scalable cell culture processes, it maintains stable agitation performance even when the liquid volume fluctuates.

Features

• MR210Bio impeller for efficient, gentle mixing
• Consistent agitation characteristics despite changing liquid levels
• PID-controlled band heater with temperatures up to 80 °C
• Seal-less magnetic drive for high sterility and reduced contamination risk
• Aeration options: SPG membrane sparger or sintered metal sparger
• Agitation range: 5–200 rpm
• Touch-panel control via S-BOX × 10α II
• Culture volumes: 2.4 L, 6 L (10% bottom), or 7 L
• Temperature accuracy: ±0.3 °C at 37 °C
• Weight: approx. 30–34 kg
• Power supply: AC 100 V, 50/60 Hz

Typical areas of application:

• Animal cell culture (e.g., CHO cells)
• Microcarrier and suspension cultures
• Scale-up from laboratory to production processes
• Fed-batch cultures with variable operating volumes

The VMF Reactor is a vertical reciprocal-motion bioreactor designed for efficient yet gentle mixing of cell cultures. Its fully closed design minimizes contamination risks while providing low-shear conditions ideal for sensitive cells, making it suitable for research, production, and GMP-compliant workflows.

Features

• Vertical reciprocal mixing: Gentle agitation with low shear stress
• Fully closed design: No rotating seals, ensuring high sterility and safety
• Touch-panel control via S‑BOX × 10α II: Temperature, motion, and PI control
• Special impeller design: Optimized for vertical movement (VM100, VM200)
• Precise temperature control: Room temperature +5 to +20 °C (standard 37 °C), ±0.3 °C accuracy
• Linear shaft drive: No mechanical seals
• Movement range: 40 mm stroke, impeller speed up to 300 mm/s
• Available volumes: 0.3 L, 1.2 L, 2.4 L, 7 L
• Power supply: AC 100 V, 50/60 Hz

Typical areas of application:

• Cultivation of shear-sensitive cells (e.g., CHO cells)
• GMP-compliant cell culture processes
• Parallel operation with multiple reactors

The Microscopic Observation System enables complete visual control of all layers of multilayer flasks and provides crucial data for quality assurance and process optimization.

Features

• Complete cell observation: Control from above (VAS-002) or below (WAS-100)
• Reproducible results: Precise image capture and documentation of each cell layer
• Customizable: Configuration according to your laboratory requirements
• Integration into existing processes: Seamless connection to incubators and automated manipulators
• Time savings: Reduces manual inspections and optimizes workflows

Typical areas of application:

• Research and development in cell therapy
• Quality control in pilot plants and production lines
• Automated cell culture analysis in GMP-compliant environments

The Automatic Manipulator WAS-111 by Shikoku Instrumentation is an advanced 3D shaking and handling system for stackable cell culture vessels such as Cell Factory, CellSTACK, and HYPERStack. The system enables simultaneous shaking, stirring, and liquid handling in multiple vessels and is designed for use in cell culture and biotechnological production environments. Thanks to its 3D motion mechanism, high load capacity, and flexible configuration, the WAS-111 is ideally suited for scalable cell culture processes and automated laboratory and production applications.

Features

• 3D shaking mechanism
  (vertical, horizontal, diagonal, and complex 3D motion)

• Simultaneous shaking, stirring, and liquid handling

• Mounts up to 3 stackable cell culture vessels
  (40- or 52-layer)

• Optional: mounts up to 6 vessels
  (e.g., 10-layer Cell Factory, 10-layer CellSTACK, or 36-layer HYPERStack)

• Compatible with Cell Factory, CellSTACK, and HYPERStack

• Adjustable shaking angles: ±0.5° to ±20° (3D)

• Shaking speed: 1–60°/s

• Tilting speed: 0.5–60°/s

• Turning, tilting, and combined motion modes

• Tilt range:

  • Right/left: −20° to +130°

  • Front/back: −20° to +40°

• Multiple shake patterns
  (3D, front/rear, right/left, combination, turning)

• Language-selectable operation screen

• Industrial-grade, robust design

• Power supply: 3-phase AC 200–230 V, 50/60 Hz, 7 kVA
  (option: AC 380–440 V)

• Dimensions: approx. 1,580 × 2,080 × 1,880 mm

• Weight: ≤ 1,000 kg (without cart)

Typical areas of application:

• Cell culture and bioprocessing
• Scale-up cell production processes
• Biotechnological R&D
• Automated shaking and mixing of cell cultures
• Liquid handling in large cell culture vessels
• Bioprocess automation
• Operation with Cell Factory, CellSTACK, and HYPERStack systems
• Pharmaceutical and biotech manufacturing environments

Features

• Fully automated cell processing: seeding, media change, cell detachment, and harvesting in one system
• Multilayer compatibility: processing multiple multilayer flasks simultaneously
• Cleanroom compatible: designed for GMP-related applications in Class B environments
• Flexible configuration: adaptable to your specific production processes
• Increased efficiency and reproducibility: Less manual intervention, higher productivity

The Automatic Manipulator takes over key steps in cell culture—from seeding and media change to cell detachment and harvesting. This reduces manual workload, minimizes contamination risks, and ensures consistently high quality.

Typical areas of application:

• Research and development in the field of cell therapy
• Pilot plants and production lines for cell therapeutics
• Vaccine and bioproduction